消化器外科

エビデンス解説動画

セプラフィルムのエビデンス

外科 大腸

Becker JM, J Am Coll Surg, 183, 297-306, 1996
Fazio VW et al, Dis Colon Rectum 49：1-11, 2006
Beck DE et al, Dis Colon Rectum 46：1310-1319, 2003

癒着防止効果

＜海外データ＞

●Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study.

Becker JM, et al. : J Am Coll Surg. ;183(4):297-306,1996.

＜国内データ＞

●ヒアルロン酸ナトリウム/カルボキシメチルセルロースを材質とした合成吸収性癒着防止材の腹部外科における臨床的検討

福島 恒男 他 : 外科治療 ;81(2):227-233,1999.

腸切除における有効性と安全性

＜海外データ＞

●Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection.

Fazio VW, et al. : Dis Colon Rectum. ;49(1):1-11,2006.

＜国内データ＞

●Hyaluronic acid-carboxycellulose membrane (Seprafilm) reduces early postoperative small bowel obstruction in gastrointestinal surgery.

Mohri Y, et al. : Am Surg. ;71(10):861-863,2005.

＜海外データ＞

●Sodium hyaluronate-based bioresorbable membrane (Seprafilm) reduced early postoperative intestinal obstruction after lower abdominal surgery for colorectal cancer: the preliminary report.

Park CM, et al. : Int J Colorectal Dis. ;24(3):305-310,2009.

肝切除における有効性と安全性

＜海外データ＞

●Use of bioresorbable membranes to reduce abdominal and perihepatic adhesions in 2-stage hepatectomy of liver metastases from colorectal cancer: results of a prospective, randomized controlled phase II trial.

Dupré A, et al. : Ann Surg. ;258(1):30-36,2013.

胃切除における有効性と安全性

＜国内データ＞

●A sodium hyaluronate carboxymethylcellulose bioresorbable membrane prevents postoperative small-bowel adhesive obstruction after distal gastrectomy.

Kawamura H, et al. : Surg Today. ;40(3):223-227,2010.

安全性

＜海外データ＞

●A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine.

Beck DE, et al. : Dis Colon Rectum. ;46(10):1310-1319,2003.